Absorption, pharmacokinetics, and safety of triclosan after dermal administration.

نویسندگان

  • Christian Queckenberg
  • Jürgen Meins
  • Bertil Wachall
  • Oxana Doroshyenko
  • Dorota Tomalik-Scharte
  • Bärbel Bastian
  • Mona Abdel-Tawab
  • Uwe Fuhr
چکیده

We evaluated the pharmacokinetics and safety of the antimicrobial agent triclosan after dermal application of a 2% triclosan-containing cream to six volunteers. Percutaneous absorption calculated from urinary excretion was 5.9% +/- 2.1% of the dose (mean +/- standard deviation). The amount absorbed suggests that daily application of a standard adult dose would result in a systemic exposure 890 times lower than the relevant no-observed-adverse-effect level. Triclosan can be considered safe for use in hydrophobic creams.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 54 1  شماره 

صفحات  -

تاریخ انتشار 2010